Isomorphous replacement

From Online Dictionary of Crystallography

Substitution isomorphe (Fr). Isomorpher Ersatz (Ge). Metodo della sostituzione isomorfa (It). 同型置換法 (Ja). изоморфное замещение (Ru). Substitución isomorfa (Sp).


A method of determining diffraction phases from the differences in intensity between corresponding reflections from two or more isomorphous crystals. Most commonly used in the determination of protein structures, where it is possible to derive isomorphous crystals of native protein and of heavy-atom derivatives.

See also

  • Molecular replacement
  • Chapter 2.3.3 of International Tables for Crystallography, Volume B
  • International Tables for Crystallography, Volume F