Difference between revisions of "Maximum likelihood"

From Online Dictionary of Crystallography

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Revision as of 10:52, 9 April 2008

An approach to structure refinement in which the parameters of a structural model are modified to optimize the statistical probability of generating a set of observed intensities. The technique is often used in the refinement of structures of biological macromolecules, where the unfavourable parameter-to-observation ratio often leads to overfitted data and consequent systematic errors in least-squares minimization procedures.